The cholinergic drug

The cholinergic drug A cholinergic drug is a drug that acts on the peripheral nervous system, the central nervous system, or both and enhances the effects that are mediated by acetylcholine. It is also known as cholinergic agent, parasympathomimetic drug or cholinergic agonist. [1][2] It can work in two ways; either acting directly by mimicking the effects of acetylcholine at one or more acetylcholine receptors present in the body, or acting indirectly by blocking/inhibiting the enzyme acetylcholine that is responsible for the degradation/ hydrolysis of acetylcholine. [1][2] Depending on the type of receptor to act on, cholinergic drugs are either classified as muscarinic agonists or nicotinic agonists. [6] Anticholinergic drugs: An anticholinergic drug is a drug or an agent that competes with the neurotransmitter acetylcholine for its binding sites at synaptic junctions thereby suppressing or inhibiting its activity and thus preventing the transmission of parasympathetic nerve impulses. [3][4] Depending on the type of receptor to act on, anticholinergic drugs are either classified as muscarinic antagonists or nicotinic antagonists. [6] Pilocarpine: (Chemical formula=C11H16N2O2) Introduction: Pilocarpine is a naturally occurring alkaloid which is extracted from the South American shrub named Pilocarpus jaborandi. It is a non-selective cholinergic parasympathomimetic agonist that binds to muscarinic-M3 receptors and results in contraction of smooth muscles and stimulation of various exocrine glands. [5] The drug is available in the form of eye drops, tablets, suspensions and gel. It has a slow onset of action which is about 10 to 15 minutes but has a longer duration of action of about 6 to 8 hours, and therefore can be given thrice a day. It is inactivated at neuronal synapses and in plasma and is excreted in urine. Pilocarpine can be used in combination with other sympathomimetics, carbonic anhydrase inhibitors, miotics, beta-blockers, or hyperosmotic agents. [8] History: In 1875, Mr. Gerrard discovered pilocarpine from the leaves of Pilocarpus jaborandi. At that time, he believed that there were at least two alkaloids present in this plant. At the same time, M. Hardy isolated pilocarpine. In 1876, the isolated pilocarpine alkaloid was introduced to conventional ophthalmology for the treatment of glaucoma. 1879, Straws, while doing an active research concerning the sudoriferous secretion in cases of facial paralysis, was the first to employ local medication with pilocarpine and published relevant results. Chemical synthesis of pilocarpine: Although pilocarpine looks like a simple molecule but it has a complex chemical synthesis. This is because of the stereospecific construction of the imidazole moiety that is cis to the ethyl group on the butyrolactone ring which makes its synthesis difficult and challenging. The starting reagent for its synthesis is 2-acetylbutyrolactone which undergoes selenenylation by reacting with phenylaelenenyl chloride to produce a seleno lactone 2-acetyl-2-(phenylselenyl) butyrolactone with a yield of 94%. This is then subjected to oxidative elimination of selenoxide in the presence of cyclo-pentadiene and hydrogen peroxide to produce a mixture of endo and exo bicycle ketones in a ratio of 2.3:1. Pyrolysis (flash vacuum thermolysis) of these ketones produces a white solid 3-acetyl-2(5H)-furanone with a yield of 95%. This ketone is then reduced under mild conditions by treating it with an asymmetric reducing agent (+)-?-chlorodiisopinocamphenylborane, which is used particularly for chiral redu ctions, to produce (3R)-3-(1-hydroxyethyl)-2(5H)-furanone in 60% chemical yield and an optical purity of >92% that was determined by NMR analysis. Next, a stereocentre is introduced at C4 of the (3R)-3-(1-hydroxyethyl)-2(5H)-furanone by the Claisen rearrangement at its vinyl ether which produces an exocyclic double bond and the (4R)-acetaldehyde side chain. Both of them are necessary for the formation of the imidazole ring. This will result in a 2:1 mixture of (4R)-(Z)-dehydrohomopilopic aldehyde and (4S)-E-diastereomer in 71% yield. Hydrogenation of (4R)-(Z)-dehydrohomopilopic aldehyde in the presence of pyridine/benzene (1:1) solution at 25?C at 1atm for 1 hour produces (3s,cis)-Homopilopic aldehyde. Finally, when (3s,cis)-Homopilopic aldehyde is reacted with 1,5-disubstituted imidazole under aprotic conditions, it results in the formation of pilocarpine in 61% yield. [9] Structure-activity relationship (SAR): The nitrogen on the imidazole ring is protonated before interacting with the muscarinic receptor. There is a strong ionic interaction between the charged nitrogen atom and an anionic side group of an aspartate residue in the receptor. The methyl substitute on the nitrogen is positioned in an open region of the binding site. Hydrogen bonding interactions exist between the ester group of pilocarpine and an asparagines residue of the cholinergic receptor. A small hydrophobic pocket exists in the receptor site which can accommodate the methyl group of pilocarpine. The drug has a correct pharmacophore for the muscarinic receptor with a separation between nitrogen and oxygen being 4.4?A. [6] Mechanism of action: Pilocarpine is a direct acting cholinergic agent that resembles acetylcholine and therefore binds to the same muscarinic neuroreceptor and results in its stimulation. In eye, it causes contraction of the iris sphincter muscle and therefore results in miosis (pupil constriction). Clinical uses: Pilocarpine has been used in the treatment of both acute closed-angle and chronic open-angle glaucoma. [8] Glaucoma is a condition when the aqueous contents of the eye cannot be drained. This result in increased intraocular pressure which causes optic nerve damage and can lead to side vision damage (peripheral vision damage) and if not treated, can result in central vision damage and leads to irreversible blindness. [6] Pilocarpine is also used to treat xerostomia which is a condition characterised by dryness of the oral mucosa. The drug acts on cholinergic receptors in the glandular parenchyma thereby increasing the salivary secretion. [7] Pilocarpine hydrochloride (Salagen) tablets are prescribed to the patients suffering from Sjà ¶gren syndrome (SS) in order to treat their symptoms of xerostomia (dry mouth) and xerophthalmia (dry eyes). Sjà ¶gren syndrome (SS) is a chronic, autoimmune, rheumatic disorder in which immune cells attack and destroy the exocrine glands that produce tears and saliva. This in turn makes the individual susceptible to various infections and if untreated may also lead to other complications like bacterial sialadenitis, bacterial conjunctivitis, stomatopyrosis (burning mouth), oral candidiasis, oral ulcers, periodontal disease, accelerated dental caries, corneal ulceration or perforation, malnutrition, weight loss and sleep disruption. [5] Pilocarpine is also used to diagnose cystic fibrosis (CF). [8] Cystic fibrosis is a common hereditary disease which is characterised by scarring (fibrosis) and formation of cyst within the pancreas. The disease is characterised by shortness of breath, frequent chest infections, sinus infections, salty tasting skin, normal appetite but poor growth and poor weight gain, excess mucus production, diarrhea and infertility in males. [14] Sweat test method is used to diagnose of disease in which the drug stimulates sweat glands in order to measure the concentration of chloride and sodium that is excreted in the sweat. Pilocarpine is often used as an antidote for Atropine, Hyoscyamine and Scopolamine poisoning. [8] Adverse effects: Since pilocarpine is a non-selective muscarinic receptor anonist, its use can result in a wide variety of side-effects which can include lacrimation, excessive perspiration, excessive salivation, bronchospasm, increased bronchial mucus secretion, muscle tremors, tachycardia, hypertension, diarrhea, blurred vision and eye pain, browache and miosis when used chronically as an eye drop. When pilocarpine is used in the form systemic injection, it can cross the blood-brain barrier and reach the brain where it can lead to chronic epilepsy. [13] Suggestions for design of new drugs: Pilocarpine has significant delivery problems associated with its low lipophilicity. Its bioavailability in the eye is low, duration of action is fast due to its rapid elimination from the eye and above all, it has serious side effects like miosis and myopia. Based on the knowledge of dependence of drug delivery with physicochemical properties of the drug, a prodrug approach can be used to improve the delivery characteristics of pilocarpine. A prodrug should be designed such that it has a higher lipophilicity than pilocarpine which would enable it to cross the corneal membrane with ease, should have sufficient aqueous solubility so that it could be formulated as eyedrops, should be able to convert back to the active parent drug within the cornea, should have a controlled release and a prolonged duration of action. [10] Curare: Introduction: Curare is a nicotinic antagonist. It is a crude, dried extract from a plant called Chondrodendron tomentosum. [6] It is a mixture of 70 alkaloids. [11] The active principle in curare is tubocurarine (C37H41N2O6). [6]The antidote for curare poisoning is an acetylcholinesterase (AChE) inhibitor (anti-cholinesterase), such as physostigmine or neostigmine. [15] The drug is available in the form of solutions and intravenous injections. It has an onset of action of about 4 to 6 minutes and duration of action of about 80 to 120 minutes. It is eliminated through kidney and liver. History of curare: During the sixteenth century, the South American indigenous people used curare as a paralyzing poison where they killed the prey by dipping the arrows or blowgun darts in curare. [16]The prey is killed due to asphyxia in which the respiratory muscles fail to contract. [16] In 1780, Abbe Felix Fontana studied the effects of curare on heart, voluntary muscles and nerves and found that it affects the voluntary muscles of the body as compared to the other two. [15] In 1800, Alexander von Humboldt reported the method used by the Orinoco River natives to prepare the curare toxin from its plant source.[16] During 1811-1812 Benjamin Collins Brodie (1783-1862), a leading English surgeon, experimented with curare. [16]He found that curare paralysed the respiratory muscles but the heart continued to beat for a while. [16]He was the first to show that if the animals respiration is maintained artificially, recovery is complete. [16] In 1850, George Harley found that tetanus or strychnine poisoning can be cured by using curare. [15] From 1887 the Burroughs Wellcome catalogue listed under its Tabloids brand name, tablets of curare at 1/12 grain (price 8 shillings) for use in preparing a solution for hypodermic injection. [15] In 1939, Henry Hallett Dale reported the antagonistic effect of curare on acetylcholine. [15] Mechanism of action: Curare is a non-depolarizing muscle relaxant that blocks the nicotinic acetylcholine receptor. The main toxin of curare, d-tubocurarine, is a competitive antagonist of acetylcholine and so occupies the same position on the receptor as the neurotransmitter but does not switch it on. The overall effect on the body is the same as it would be in the absence of acetylcholine. [15] History of tubocurarine: In 1935, Harold King of London was experimenting on a sample of curare in Sir Henry Dales laboratory and was not only able to isolate tubocurarine in its pure form from the crude drug but also discovered its chemical structure. [16] In 1912, tubocurarine was used for the first time in medicine. [15] In 1942, tubocurarine was used along with anaesthetics in surgical procedures to relax muscles. [15] Structure-activity relationship: The structure of tubocurarine is shown in fig. Although the molecule does not have an ester group to bind to the nicotinic receptor, but it has two positively charged nitrogen atoms, one of which is a tertiary nitrogen atom while the other is a quaternary nitrogen. One of them binds to the anionic binding region of the nicotinic receptor while the other binds to a nearby cysteine residue that is 0.9-1.2nm away. Such an intreraction is so strong that it makes up for the lack of the ester binding interaction. Also, the distance between the two positive centres is 1.15nm which is also important for the activity of the drug. [6] Indication Curare is used in the diagnosis of myasthenia gravis, [17]which is an autoimmune disease in which antibodies are produced against acetylcholine nicotinic post synaptic receptors at the neuro-muscular junction. [18] Curare is also used in surgical procedures in association with general anesthesia in order to facilitate in the relaxation of abdominal muscles when it is not possible with inhalation anesthesia. [12] Adverse effects: Curare has undesirable side-effects, the most common of which include hypotension (by ganglion-block and histamine release), bronchoconstriction (by histamine release), skeletal muscles paralysis and asphyxia (impaired breathing). [15] Suggestions for design of new drugs: Tubocurarine has undesirable side effects because it also acts as an antagonist at the nicotinic receptors of the autonomic nervous system. Also, its deactivation depends on metabolic mechanisms involving enzymatic deactivation and/or excretion, the efficiency of which varies from patient to patient and is particularly poor for patients with low levels of plasma esterases or kidney failure. Therefore, a self-destruct mechanism can be introduced into the design of a new drug for its sufficiently rapid breakdown. If a good electron withdrawing group is introduced on to a carbon that is beta to the quaternary nitrogen centre, Hofmann elimination is possible under the slightly alkaline pH of blood (pH = 7.4) and body temperature. The electron-withdrawing groups will function to increase the acidity of the hydrogen on the beta-carbon such that it is easily lost. Thus by introducing such a group, the drug is inactivated and is unable to bind to its receptor due to the loss of the positive charge on the quaternary centre and is split into two molecules. Thus deactivation occurs at a constant rate between patients. [6]

Business and technology Essay

The second issue centered on the impact of distance-delivery on the effectiveness of health care. The third issue involved a determination of the effects that the use of electronic communications have on health care delivery today. The fourth issue required a projection of the likely affects that the continued use of electronic communications will have on health care delivery. These interrelated issues are addressed in separate discussions in this paper. Electronic Communications as an External Delivery Mechanism When considering the ways in which electronic communications may be applied effectively as an external delivery mechanism in the communication of patient- pecific information, it is useful to first (a) identify the parties who will likely be involved in such interchanges and to (b) determine the types of information most likely to be exchanged. Further, depending upon of types of information likely to be exchanged it is also useful to consider how and in what form such information is developed (Committee on Redesigning Health Insurance Performance Measures, Payment, and Performance Improvement Programs, 2006; Committee on Public Health Strategies to Improve Health Board on Population Health and Public Health Practice, 2012; World Health Organization, 2008). The party-pairs most likely to be involved in electronic communications exchanges are (a) provider-to-patient, (b) patient-to-provider, (c) provider-to-provider, and (d) provider-to-parties other than patients and other providers (Committee on Redesigning Health Insurance Performance Measures, Payment, and Performance Improvement Programs, 2006; Committee on Public Health Strategies to Improve Health Board on Population Health and Public Health Practice, 2012; World Health Organization, 2008). In these instances especially so in provider-to-parties other than patients and other providers, the ssues of patient privacy and the integrity of patient-specific data must be an important tocal point (McGraw, 2 The types ot patient-specific intormation likely to be exchanged between providers and patients, regardless of the direction of the initial contract in such exchanges, are (a) patient symptoms and concerns, (b) provider care directions and queries to patients concerning their clinical conditions. The types of patient-specific information most likely to be exchanged among providers are (a) requests for the conduct of examinations and other procedures and b) consultations concerning the appropriate treatment protocols for specific patients. The types of patient-specific information most likely to be exchanged between providers and parties other than patients and other providers are (a) patient-specific data required by administrative personnel for scheduling and billing purposes and (b) patient specific data required by health care funders for purposes of specific treatment authorizations (Committee on Redesigning Health Insurance and Public Health Practice, 2012; World Health Organization, 2008).

Quantitative Research Essay - 1294 Words

Quantitative Research Quantitative research is based on statements such as anything that exists exists in a certain quantity and can be measured. While Thorndike’s statement from 1904 appears to be fairly innocent and direct, it staked an important philosophical position that has persisted in social science research throughout most to this century. (Custer, 1996, p. 3). In 1927, William F. Ogburn successfully lobbied to have Lord Kelvin’s motto: When you cannot measure, your knowledge is meager and unsatisfactory prominently and permanently carved onto the face of the University of Chicago’s social science research building. In this decade, however, the competing paradigms of quantitative and qualitative research have become†¦show more content†¦Qualitative methods, on the other hand, are appropriate when the phenomena under study are complex, are social in nature, and do not lend themselves to quantification (Liebscher, 1998, p. 669). Quantitative research is based primarily on positivistic thought and qualitative research is more constructivist in theory. Until recently, the strict scientific methods employed by quantitative analysis have been considered the best way to conduct any meaningful research. The positivist notion that qualitative data is inherently untrustworthy and therefore to be avoided is untenable. Arguments are advanced to support the view that social research is based on ‘qualitative knowing’ and that quantification extends, refines, and cross-checks qualitative knowledge (Howe, 1985, p. 10). In other words, current thought holds that the two paradigms are not mutually exclusive and could very well support each other in most social science inquiry. To disparage qualitative data as subjective is to accuse it of having high fallibility; to laud the objectivity of quantitative data is to construe it as having low fallibility (Howe, 1985, p. 13). At first glance, quantitative data might appear to be uniformly superior. For example, There are x students in the classroom is an instance of quantifiable research. By contrast, observing the workings of a classroom in terms of the group dynamicsShow MoreRelatedQuantitative Research Methods For Research1077 Words   |  5 PagesQuantitative research methods are typically concerned with measuring criminological or criminal justice reality. There are a number of different quantitative research methods available to researchers, most of which fall under the rubric of a research design, which can be defined as the plan for a study that includes the exploratory, descriptive, explanatory and evaluative of an investigation. Purpose of exploratory research is to identify context, issues and concerns whereas descriptive is to provideRead MoreQuantitative Research : Data Collection1527 Words   |  7 PagesQuantitative research involves the collection and converting of data in numerical form to enable statistical calculations be made and conclusions drawn. It provides a measure of how people think, feel or behave and uses the statistical analysis to determine the results. However, this measurement result in numbers, or data, being collected, which is then analyzed by using quantitative research methods (Byrne, 2007). In quantitative research, data collection involves the gathering of informationRead MoreQuantitative And Qualitative Research Methods871 Words   |  4 PagesWith sociology, researchers can use a different range of research methods to acquire new data. The various forms of research methods include surveys, ethnomethodology, experiments and documentary research. A common distinction is often made in sociology between quantitative and qualitative research methods. Quantitative methods intend to measure social phenomena by using mathematical methods and statistical analysis. On the other hand, qualitative methods mean to collect rich, detailed data, allowingRead MoreComparing Quantitative and Qualitative Research1586 Words   |  7 PagesCOMPARING QUANTITATIVE AND QUALITATIVE RESEARCH Social theory is a â€Å"system of interconnected ideas that condenses and organises the knowledge about the social world and explains how it works† (Neuman, 2006, p.8) and for many years scientists have gathered data using specialised techniques such as Quantative and Qualitative research to support or reject these theories. Quantitative research â€Å"generates numerical data or information that can be converted into numbers,† (Experiment Resources, 2009,Read MoreQuantitative Research : Data Collection1562 Words   |  7 Pages Quantitative research involves the collection and converting of data in numerical form to enable statistical calculations be made and conclusions drawn. It provides a measure of how people think, feel or behave and uses the statistical analysis to determine the results. However, this measurement result in numbers, or data, being collected, which is then analyzed by using quantitative research methods (Byrne, 2007). In quantitative research, data collection involves the gathering of informationRead MoreMethodology And Methods Of Quantitative Research1627 Words   |  7 Pagesaim is to give an outlined loom of how to extract and collects the grouped primary research data by way of responding to the research topic in the most appropriate manner. Notions and philosophies that emphasize the right procedures are taken into account in the way of effecting judicious methodology. The methodology area identifies, clarifies and explains the approaches that will be taken to lead primary research and confirms any misunderstanding, or contradicts what has been discovered in the literatureRead MoreComparative Research On Quantitative Research1065 Words   |  5 Pagesthat is utilized in this study is a quantitative method. This method was chosen in order for the researcher to see the statistical side of the data collected. â€Å"Quantitative research also called â€Å"empirical research,† refer s to any research based on something that can be accurately and precisely measured.† (Nursing Resources: Qualitative VS. Quantitative, 2017). Within the study of the quantitative method was casual-comparative research. Casual-comparative research tends to identify how different groupsRead MoreQuantitative And Quantitative Research Methods1520 Words   |  7 PagesResearch is a process that is systematic and gathers, analyzes and interprets data collected about a specific subject with the objective of better understanding and meeting a goal (Leedy Ormond, 2010). Before initiating the research process the researchers need to have a clear understanding of the question and the goal of what is going to be studied or investigated. The development of a plan designed with specific methods needs to be included to acquire relevant data. The research should be guidedRead MoreResearch Methods Of Quantitative Research1087 Words   |  5 Pages Week 2 Assignment Adam Morrison PSY 326 Research Methods Jessica Lee Qualitative researchers are focused on interpreting and making sense out of what they observe rather than trying to simplify and quantify these observations by collecting and observing people, places and things in their natural setting. In doing this, researchers are able to investigate hypothesis with more freedom and rigidity while accepting the fact that they relinquish their ability to control direct and indirectRead MoreQualitative Research : Quantitative Research Essay814 Words   |  4 PagesQualitative research is a kind of of scientific research which consists of an analysis that look for answers to a question, systematically uses a specific procedures to answer the question, gathers evidence, generate findings that are legit farther the limits of the study. Qualitative research has these characteristics. As an addition, it looks for to analyze the research problem or motif from the aspect of the local people who involves the study. Qualitative research is particularly e ffective

Mapp V. Ohio ( 1961 ) - 1619 Words

Mapp v. Ohio (1961), was a milestone case in criminal procedure, in which the United States Supreme Court decided that evidence obtained in violation of the Fourth Amendment, which protects against unreasonable searches and seizures,† which cannot be used in the law on the state level or in criminal prosecutions in state courts, and in addition, federal criminal law prosecutions in federal courts (MAPP v. OHIO. They Oyez Project at IIT Chicago-Kent College of Law.) The Supreme Court successfully completed this by use of selective incorporation. In Mapp the association was within the incorporation of the provisions, of the Fourth Amendment which are appropriate only to actions of the federal government into the Fourteenth Amendment due process clause which is relevant to actions of the states. (Mapp v. Ohio, 367 US 643 (1961)) The paper will follow with the facts prior to the issue which led to the arrest of Dollree Mapp, Next it will then go forth with the facts presenting the issue for the case and the courts majority opinion, along with dissenting opinions. Then we look at the political and philosophical context of the case which deal with the individuals rights. Then lastly I will give my own personal commentary, and present the conclusions for the class. Ms. Dollree Mapp was living in Cuyahoga county Ohio, in a residential neighborhood who owned her own home, and lived in a two family house on the second floor with her eleven year old daughter. The Police officers inShow MoreRelatedSupreme Court Cases that Affected Society: The Mapp V. Ohio Case of 1961641 Words   |  3 Pagesstill got away with the crime. It just goes to show there is a flaw in the court system, but again, a different subject. In the case Mapp V. Ohio of 1961, police forced their way into Dollree Mapps, house, suspecting her of harboring a suspected bomber. No suspect was found and Mapp was arrested of possessing obscene pictures and was convicted in an Ohio court. Mapp appealed to the United States Supreme Court and the decision was made that the Supreme Court said â€Å"evidence seized unlawfully, withoutRead More Mapp v. Ohio Fourth Amendment Case Essay1284 Words   |  6 PagesMapp v. Ohio: Controversy of the Fourth Amendment Ms. Dollree Mapp and her daughter lived in Cleveland, Ohio. After receiving information that an individual wanted in connection with a recent bombing was hiding in Mapps house, the Cleveland police knocked on her door and demanded entrance. Mapp called her attorney and subsequently refused to let the police in when they failed to produce a search warrant. After several hours of surveillance and the arrival of more officers, the police again soughtRead MoreConstitutional Policing Essay992 Words   |  4 Pagesis clearly broken in the case of Weeks v. United States, it was a United States Supreme Court case in which the Court unanimously held that the warrantless seizure of items from a private residence constitutes a violation of the Fourth Amendment. It also prevented local officers from securing evidence by means prohibited under the federal exclusionary rule and giving it to their federal colleagues. It was not until the case of Mapp v. Ohio, 367 U.S. 643 (1961), that the exclusio nary rule was deemedRead MoreExclusionary Rule: How, When, and Why Was it Established? Essay examples967 Words   |  4 Pagesthat was attained by illegal searches and seizures was allowed (Tinsley Kinsella, 2003). During this period, the protections of the Fourth Amendment were unfilled words to persons condemned until 1914 in the case of Weeks v. United States. In the 1914 landmark case of Weeks v. United States, the Supreme Court created the exclusionary rule and was effectually created to protect people against unreasonable searches and seizures of the federal agents. The Court held that belongings or any evidenceRead MoreMapp Vs. Ohio State1291 Words   |  6 PagesMapp vs. Ohio State(1961) Background: In the Mapp vs Ohio state court case, the issue disputed was when the appellant Dollree Mapp was convicted of possessing â€Å"obscene† materials after an illegal police search of her home for a fugitive. During the year of 1961, Ohio police were looking for a criminal accused of a bombing and had been told that he was hiding in Dollree Mapp s house. Police acted quickly and came to her house but when she didn t answer the door, police officers forced themselvesRead MoreMapp vs Ohio Essay1362 Words   |  6 PagesOn May 23rd 1957, three police officers representing Cleveland Ohio came to the door of Miss Mapp’s residence with the suspicion of a bombing suspect hiding out in her home. Miss Mapp and her daughter lived in a two family two story home. Upon their arrival at the house the police knocked on the door and demanded entrance from Miss Mapp. However Miss Mapp didn’t open the door and instead asked them to provide a search warrant after she called her attor ney. The officers advised their headquartersRead MoreEarl Warren Served As Chief Justice1441 Words   |  6 Pagesfrom 1961 to 1969, Warren Court presided over the criminal justice system in the United States, using the 4th and 14th Amendment to extend constitutional protections to all courts in every State. This is known as the â€Å"nationalization† of the Bill of Rights. In these years, cases pertaining to the right to legal counsel, confessions, searches, and the treatment of juvenile criminals all happen during. The Warren Court s modification in the criminal justice system began with the case of Mapp v. OhioRead MoreThe Effects of the Exclusionary Rule600 Words   |  3 Pagesnumerous problems with its interpretation and has had several exceptions added to it. In 1961, a landmark case Mapp v. Ohio brought further interpretation of the Fourth Amendment. On May 23, 1957, police officers acting on information that a suspect in a bombing case and illegal betting equipment could be found in the residence of Dollree Mapp. The officers then went to the Mapp residence and demanded entrance. Mapp requested to see their warrant to search the house, which they did not have. After watchingRead MoreOhio V. United States in Violations from the Constitution512 Words   |  2 Pagesand it makes it a violation of the fourth amendment. Justice Black mentioned in his concurrence that if something is obtained illegally, it cannot be used again the appellant. The Boyd’s case was not the only case mentioned in the Mapp v. Ohio opinion. Additionally, Weeks v. United States (1914) was a case that determined the warrantless seizure of items from an individual is a violation of the Fourth Amendment. The police seized a few papers from Freemont Weeks’s home and he was charged with transportingRead MoreThe Legal Rule Of The Court Essay1585 Words   |  7 Pagespossibly cause a prosecutor to lose their case in court and hinder them from delivering justice. The Supreme Court case that originally created the exclusionary rule was Weeks v. United States (1914). In this case, Freemont Weeks was arrested on December 21, 1914 and convicted of transporting lottery tickets through the mail (Weeks v. United States). He was arrested at the Union Station in Kansas City, Missouri where he was currently employed. Police took him into custody and that is when actions that